Hybrid de novo genome assembly of red gromwell (Lithospermum erythrorhizon) reveals evolutionary insight into shikonin biosynthesis

摘要

Intact roots of producing shikonin. Hairy root culture of producing shikonin. The structures of shikonin and its enantiomer, alkannin. Shikonin and alkannin are precursor to dozens of acylated derivatives collectively produced by members of the Boraginaceae. The shikonin pathway starts with the conjugation of 4-hydroxybenzoic acid (4HBA) and geranyl diphosphate (GPP) catalyzed by -hydroxybenzoate:geranyltransferase (PGT)