Biphasic Outbreak of Invasive Group A Streptococcus Disease in Eldercare Facility New Zealand

摘要

A 3-month outbreak of invasive group A disease at an eldercare facility, in which 5 persons died, was biphasic. Although targeted chemoprophylaxis contained the initial outbreak, a second phase of the outbreak occurred after infection control processes ended. To retrospectively investigate the genomic epidemiology of the biphasic outbreak, we used whole-genome sequencing and multiple bioinformatics approaches. Analysis of isolates from the outbreak and isolates prospectively collected during the outbreak response indicated a single S 81 clone among residents and staff members. Outbreak isolates differed from nonoutbreak 81 isolates by harboring an integrative conjugative genomic element that contained the macrolide resistance determinant (TR). This study shows how retrospective high-resolution genomic investigations identified rapid spread of a closed-facilty clonal outbreak that was controlled, but not readily cleared, by infection control management procedures.