Folate functionalized pH-sensitive photothermal therapy traceable hollowmesoporous silica nanoparticles as a targeted drug carrier to improve the antitumor effectof doxorubicin in the hepatoma cell line SMMC-7721

摘要

In this paper, we prepared doxorubicin-loaded folic acid-functionalized pH-sensitivephotothermal therapy (PTT) traceable hollow mesoporous silica nanoparticles (DOX-HPCF) asa drug carrier for liver cancer treatment. According to TEM characterization, hollowmesoporous silica nanoparticles (HMSN) are monodispersed spherical particles with hollowstructure. drug release experiments showed that HPCF exhibitedpH-sensitive release. Cell uptake experiments showed that HPCF was successfully absorbedby SMMC-7721 cells. In addition, DOX-HPCF significantly inhibited the proliferation ofSMMC-7721 cells, and the near-infrared (NIR) light group showed a more obvious inhibitoryeffect. anti-tumor experiments showed that DOX-HPCF-assisted PTTinhibited tumor growth significantly. Therefore, HPCF is a promising photothermotherapycarrier for the treatment of liver cancer.