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Data on the link between genomic integration of IS1548 and lineage of the strain obtained by bioinformatic analyses of sequenced genomes of Streptococcus agalactiae available at the National Center for Biotechnology Information database

机译:通过国家生物技术信息中心提供的无乳链球菌测序基因组生物信息学分析获得的IS1548基因组整合与菌株谱系之间联系的数据

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摘要

IS , a 1316-bp element of the IS family affects the expression of several genes of the opportunistic pathogen Furthermore, certain lineages of are more frequently associated to particular diseases than other [1, 2]. We took advantage of the release of the genome sequences of a huge number of epidemiologically unrelated strains of various origin to analyze the prevalence of IS among strains. To this end, genome available at the National Center for Biotechnology Information (NCBI) database were blasted with IS DNA sequences. A sequence type (ST), based on the allelic profile of seven housekeeping genes, was assigned to each strain possessing IS . These strains were then grouped into clonal complexes (CCs). The data obtained will give the opportunity to compare the sequenced genomes of based on their lineage and/or possession of IS , and to select the corresponding strains for comparative experimental studies. The data is related to the research article « Dual and divergent transcriptional impact of IS insertion upstream of the peptidoglycan biosynthesis gene of ” [2].
机译:IS,IS家族的一个1316 bp的元件会影响机会病原体的几个基因的表达。此外,某些谱系与其他疾病相比,与其他疾病的相关性更高[1、2]。我们利用了多种流行病学上无关的各种来源的菌株的基因组序列的释放来分析菌株中IS的患病率。为此,将国家生物技术信息中心(NCBI)数据库中可用的基因组与IS DNA序列相结合。基于七个管家基因的等位基因特征,将序列类型(ST)分配给每个具有IS的菌株。然后将这些菌株分组为克隆复合物(CCs)。获得的数据将有机会根据其谱系和/或IS的占有率比较已测序的基因组,并选择相应的菌株进行比较实验研究。该数据与研究文章«IS插入肽聚糖生物合成基因上游的双重和不同转录影响有关[2]。

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