A Calm Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

摘要

Pathogenic role of involved in atopic dermatitis. expresses superantigens, such as SE and TSST-1, which activate basophils and mast cell and cause histamine release; activates LC releasing IL-4, IL-5, and IL-13, which induces AMP reduction and Th2 differentiation and inflammation; stimulates KC releasing proinflammatory cytokines including TSLP, IL-8, IL-18, and IL-1β and biofilm can induce KC apoptosis releasing inflammatory cytokines; can release δ-toxin inducing mast cell degranulation. SE staphylococcal enterotoxin, TSST-1 toxic shock syndrome toxin-1, LC Langerhans cell, TSLP thymic stromal lymphopoietin, IL interleukin, KC keratinocyte