Extension of weight-standardized bone mineral content in osteoporosis diagnosis

摘要

We appreciate the attentive and interesting article “ ” written by Liu The authors have nicely shown bones are three dimensional tissues, only volumetric bone mineral density (vBMD) can be regarded as completely standardized, since the areal bone mineral density (aBMD) is two-dimensional and could result in missed diagnosis in subjects with large bones and misdiagnosis in those with small bones. In addition, although vBMD has undeniable advantages, the most sophisticated dual-energy X-ray absorptiometry (DXA) instrument is not able to measure the bone volume . Therefore, they attempted to use weight-standardized bone mineral content (wBMC) to replace vBMD for osteoporosis diagnosis, such missed diagnosis or misdiagnosis may be avoided.