PDL1 blockage increases fetal resorption and Tfr cells but does not affect Tfh/Tfr ratio and B-cell maturation during allogeneic pregnancy

摘要

Adult female BALB/c and male C57BL/6 mice were co-caged in a 2:1 ratio and the presence of a vaginal-plug was taken for embryonic day 0.5 (E0.5). – Representative flow cytometric plots ( , ) and cumulative data ( ) illustrating the percentage of CXCR5 PD-1 Foxp3 population gated in CD4 T cells derived from the PB, spleen, thymus and uterus of maternal mice on E11.5 ( , ) as well as from the uterus on E18.5 ( , ). Each symbol reflects the data from a single mouse (  ≥ 7 mice per group) and the data are representative of two independent experiments. The cells are gated in CD4 T cells. Data were assessed statistically using one-way ANOVA followed by Tukey’s multiple-comparison test. PB peripheral blood; hi high; ***