Kupffer Cell TLR2/3 Signaling: A Pathway for EGCG Amelioration of Ethanol-Induced Hepatic Injury

机译：Kupffer细胞TLR2 / 3信号传导：乙醇诱导的肝损伤的EGCG改善途径

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Alcohol-induced liver injury is mediated through TLR2 but inhibited by TLR3 signaling. ECGC can effectively suppress alcohol-induced liver injury by inducing IL-10 expression and M2 polarization. The ECGC-mediated inhibitory effect on alcohol-induced liver injury is mediated by activating TLR3 and inhibiting TLR2 in Kupffer cells.

机译：酒精诱导的肝损伤通过TLR2介导，但被TLR3信号传导抑制。 ECGC可通过诱导IL-10表达和M2极化来有效抑制酒精引起的肝损伤。 ECGC介导的对酒精诱导的肝损伤的抑制作用是通过激活Kupffer细胞中的TLR3和抑制TLR2介导的。

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期刊名称 Cellular and Molecular Gastroenterology and Hepatology
作者
Torrey Y. Czech; Ekihiro Seki;
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年(卷),期 2020(9),1
年度 2020
页码 -1
总页数 2
原文格式 PDF
正文语种
中图分类免疫学;
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专利

1. Asiatic Acid from Potentilla chinensis Attenuate Ethanol-Induced Hepatic Injury via Suppression of Oxidative Stress and Kupffer Cell Activation [J] . Jinbin Wei, Quanfang Huang, Renbin Huang, Biological & pharmaceutical bulletin . 2013,第12期

机译：委陵菜的亚洲酸通过抑制氧化应激和库普弗细胞活化来减轻乙醇引起的肝损伤
2. Piroxicam and meloxicam ameliorate hepatic oxidative stress and protein carbonylation in Kupffer and sinusoidal endothelial cells promoted by ischemia-reperfusion injury. [J] . Montalvo Jave EE, Ortega Salgado JA, Castell A, Transplant international : . 2011,第5期

机译：吡罗昔康和美洛昔康改善了缺血再灌注损伤促进的库普弗和窦性内皮细胞的肝氧化应激和蛋白羰基化。
3. Selenium ameliorates Staphylococcus aureus-induced inflammation in bovine mammary epithelial cells by inhibiting activation of TLR2, NF-κB and MAPK signaling pathways [J] . Heng Wang, Chongliang Bi, Yinjie Wang, BMC Veterinary Research . 2018,第1期

机译：通过抑制TLR2，NF-κB和MAPK信号传导途径的激活，硒改善了牛乳腺上皮细胞中的金黄色葡萄球菌诱导的炎症
4. Protective Role of N-Acetyl-L-Tryptophan against Hepatic Ischemia-Reperfusion Injury by the TLR4/NF-KB Signaling pathway [C] . Jianxin Wang, Shuna Yu, Huiting Li, International Conference on Frontiers of Biological Sciences and Engineering . 2019

机译：N-乙酰-1-色氨酸对TLR4 / NF-KB信号通路对肝缺血再灌注损伤的保护作用
5. Alcohol increases hepatic oxygen consumption by affecting communication between Kupffer cells and parenchymal cells. [D] . Qu, Wei. 1996

机译：酒精会影响Kupffer细胞与实质细胞之间的通讯，从而增加肝脏耗氧量。
6. Divergent Roles of Kupffer Cell TLR2/3 Signaling in Alcoholic Liver Disease and the Protective Role of EGCG [O] . Pingping Luo, Fei Wang, Nai-Kei Wong, 2020

机译：库普弗细胞TLR2 / 3信号在酒精性肝病中的不同作用和EGCG的保护作用
7. Divergent Roles of Kupffer Cell TLR2/3 Signaling in Alcoholic Liver Disease and the Protective Role of EGCG [O] . Pingping Luo, Fei Wang, Nai-Kei Wong, 2020

机译：Kupffer细胞TLR2 / 3信号传导在酒精性肝病中的发散角度以及EGCG的保护作用

Kupffer Cell TLR2/3 Signaling: A Pathway for EGCG Amelioration of Ethanol-Induced Hepatic Injury

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