Sodium-glucose cotransporter 2 inhibitors antagonize lipotoxicity in human myeloid angiogenic cells and ADP-dependent activation in human platelets: potential relevance to prevention of cardiovascular events

摘要

Pro-inflammatory cytokine/chemokine gene expression. Gene expression of pro-inflammatory cytokine/chemokine was assessed in MAC pre-treated with empagliflozin ( ) or dapagliflozin ( ) at different concentrations (1–10–100 µM) for 16 h followed by 3 h of stearate 100 µM incubation ( empagliflozin,  dapagliflozin, interleukin, tumor necrosis factor-α, monocyte chemoattractant protein,  stearate). Data are expressed as mean ± SEM from at least 4 independent experiments (*p §p