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A plasma calcium-phosphorus product can be used to predict the lifespan of dogs with chronic kidney disease

机译:血浆钙磷产品可用于预测患有慢性肾脏疾病的狗的寿命

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摘要

A serum calcium-phosphorus (sCaPP) product was assessed for prediction of survival in dogs affected with chronic kidney disease (CKD). Dogs (N = 150) were retrospectively studied and followed up to determine their lifespan using 25 healthy dogs as controls. Blood and urine analyses were performed and blood pressure was measured. The dogs were divided into groups according to sCaPP (higher or lower than 70 mg /dL ) and International Renal Interest Society (IRIS) stage (IRIS 1–4). Shorter survival was observed with sCaPP > 70 mg /dL compared to dogs with sCaPP < 70 mg /dL [45.48 days (range: 5.8 to 149 days) 505.40 days (range: 113.31 to 539.52 days), mean (95% confidence interval); ≤ 0.001 respectively]. Similarly, dogs with advanced IRIS stages showed higher levels of sCaPP [mean (95% confidence interval) in mg /dL ; IRIS 1: 42.83 (range: 29.58 to 62.10); IRIS 2: 63.18 (range: 46.34 to 90.09); IRIS 3: 95.57 (range: 88.34 to 127.19); IRIS 4: 130.38 (range: 125.16 to 153.52)], accompanied by lower survival rates. Therefore, sCaPP could represent a valuable tool in the prognosis of canine CKD.
机译:评估血清钙磷(sCaPP)产物对患有慢性肾脏病(CKD)的狗的存活率的预测。对狗(N = 150)进行回顾性研究,并使用25只健康狗作为对照,以确定其寿命。进行血液和尿液分析并测量血压。根据sCaPP(高于或低于70 mg / dL)和国际肾脏兴趣协会(IRIS)阶段(IRIS 1-4)将狗分为几组。与sCaPP <70 mg / dL的狗相比,sCaPP> 70 mg / dL的存活期较短[45.48天(范围:5.8至149天)505.40天(范围:113.31至539.52天),平均值(95%置信区间) ;分别≤0.001]。同样,具有较高IRIS阶段的狗表现出较高水平的sCaPP [平均值(95%置信区间),单位mg / dL; IRIS 1:42.83(范围:29.58至62.10); IRIS 2:63.18(范围:46.34至90.09); IRIS 3:95.57(范围:88.34至127.19); IRIS 4:130.38(范围:125.16至153.52)],并伴有较低的生存率。因此,sCaPP可能是犬CKD预后的有价值的工具。

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