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Structure-based screening of chemical libraries to identify small molecules that are likely to bind with the SET and RING-associated (SRA) domain of Ubiquitin-like PHD and Ring Finger-containing 1 (UHRF1)

机译：基于化学库的结构筛选以鉴定可能与泛素样PHD和含无名指1（UHRF1）的SET和RING相关（SRA）域结合的小分子

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摘要

Overview of data files/data sets

机译：数据文件/数据集概述

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期刊名称 BMC Research Notes
作者
Debasis Patnaik;
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作者单位

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年(卷),期 2020(13),-1
年度 2020
页码 -1
总页数 5
原文格式 PDF
正文语种
中图分类
关键词
Cancer; UHRF1; SRA domain; UHRF1 inhibitor; DNA methylation; DNMT1; Structure-based screening; Virtual screening;

机译：癌症;UHRF1;SRA结构域;UHRF1抑制剂;DNA甲基化;DNMT1;基于结构的筛选;虚拟筛选;

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专利

1. The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence [J] . Hyun-Jung Jung, Hae-Ok Byun, Byul A. Jee, The Journal of biological chemistry . 2017,第9期

机译：具有PHD和无名指域1（UHRF1）/ DNA甲基转移酶1（DNMT1）轴的泛素样蛋白是细胞衰老的主要调控因子。
2. The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence [J] . Hyun-Jung Jung, Hae-Ok Byun, Byul A. Jee, The Journal of biological chemistry . 2017,第9期

机译：具有PHD和无名指域1（UHRF1）/ DNA甲基转移酶1（DNMT1）轴的泛素样蛋白是细胞衰老的主要调控因子。
3. Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation [J] . Myrianthopoulos Vassilios, Cartron Pierre Francois, Liutkeviciute Zita, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2016,第Null期

机译：针对UHRF1的SRA结构域的串联虚拟筛选鉴定了调节DNA甲基化的新型化学工具
4. Predicting and analyzing DNA-binding domains using a systematic approach to identifying a set of informative physicochemical and biochemical properties [C] . Hut-Lin Huang, Che Lin, Yi-Fan Liou, Asia-Pacific Bioinformatics Conference . 2012

机译：使用系统方法预测和分析DNA结合结构域，鉴定一组信息化学和生化特性
5. mRNA Display selection of a novel activated leukocyte cell adhesion molecule (ALCAM) binding protein from a modified combinatorial protein library based on the tenth domain of human fibronection III (10FnIII). [D] . Park, Ann Nahhyun. 2015

机译：从基于人纤维蛋白III（10FnIII）的第十个域的修饰的组合蛋白文库中选择新型激活白细胞粘附分子（ALCAM）结合蛋白的mRNA显示。
6. Targeting the SET and RING-associated (SRA) domain of ubiquitin-like PHD and ring finger–containing 1 (UHRF1) for anti-cancer drug development [O] . Debasis Patnaik, Pierre-Olivier Estève, Sriharsa Pradhan 2018

机译：针对泛素样PHD和含无名指的1（UHRF1）的SET和RING相关（SRA）域进行抗癌药物开发
7. Targeting the SET and RING-associated (SRA) domain of ubiquitin-like, PHD and ring finger-containing 1 (UHRF1) for anti-cancer drug development [O] . Debasis Patnaik, Pierre-Olivier Estève, Sriharsa Pradhan 2018

机译：靶向泛素样，PHD和含有含有环手指1（UHRF1）的抗癌药物发育的组和环形相关（SRA）结构域

Structure-based screening of chemical libraries to identify small molecules that are likely to bind with the SET and RING-associated (SRA) domain of Ubiquitin-like PHD and Ring Finger-containing 1 (UHRF1)

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