NTP42 a novel antagonist of the thromboxane receptor attenuates experimentally induced pulmonary arterial hypertension

摘要

Expression of the IP and TPα/TPβ in control and PAH lung tissue. Representative photomicrographs of haematoxylin and eosin (H&E) and immunohistochemical staining for I Prostanoid (IP) and both TPα and TPβ isoforms of the T Prostanoid receptor (TP), in lungs isolated from ( ) control individuals and ( ) PAH patients. In both and , macro images of pulmonary arteries are shown in subpanels (i) and (iv). To enable examination of vascular endothelial and smooth muscle staining, higher magnifications of the pulmonary artery wall, delineated by dotted lines in subpanels (i) and (iv), are displayed in the corresponding subpanels (ii) & (iii) and (v) & (vi), respectively. Within the macro image for each set of panels, black bars representing the respective scale and the magnification of the capture are also displayed. Arrows in the panels highlight example regions referred to in the text. Red arrows highlight vascular endothelium. Blue and green arrows highlight regions of inflammation and alveolar macrophages, respectively