A novel algorithm for alignment of multiple PPI networks based on simulated annealing

摘要

Protein function is a fundamental problem that attracts many researchers in the fields of both molecular function and evolution. Proteins were involved in almost all life processes and pathways. Although many researchers have put a great of efforts to develop public protein annotation databases, such as Uniprot [ ], NCBI protein, RCSB PDB [ ] and HPRD [ ], the task of protein characterization is far to be completed. Thanks to the development of next-generation sequencing [ ], computational methods become a major strength for discovering the molecular function and phylogenetic [ – ].