Defects in CISD-1 a mitochondrial iron-sulfur protein lower glucose level and ATP production in Caenorhabditis elegans

摘要

CDGSH iron sulfur domain-containing protein 1 (CISD-1) belongs to the CISD protein family that is evolutionary conserved across different species. In mammals, CISD-1 protein has been implicated in diseases such as cancers and diabetes. As a tractable model organism to study disease-associated proteins, we employed in this study with an aim to establish a model for interrogating the functional relevance of CISD-1 in human metabolic conditions.