AMPK Activation of Apoptotic Markers in Human Breast Cancer Cell Lines with Different p53 Backgrounds: MCF-7 MDA-MB-231 and T47D Cells

摘要

Downregulation of AMPK has been established as a major contributor to carcinogenesis in many types of human cancer. We sought to investigate the influence of activated AMPK on apoptotic markers in human breast cancer cells differing in their status, as well as estrogen receptor status (MCF-7 ( + and ), MDA-MB-231 ( mutant and ) and T47D ( mutant and )).