Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria

摘要

This study was conducted in a 14-bed medical–surgical intensive care unit (ICU) in a university-affiliated cancer center. The study was approved by the institutional review board. Patients received meropenem as a standard of care as decided by the treating intensivist. Written informed consent was obtained from the patients or their legal representatives at the time of ICU admission for blood sample collection for meropenem assay.