DONOR PRETREATMENT WITH Flt-3 LIGAND AUGMENTS ANTIDONOR CYTOTOXIC T LYMPHOCYTE NATURAL KILLER AND LYMPHOKINE-ACTIVATED KILLER CELL ACTIVITIES WITHIN LIVER ALLOGRAFTS AND ALTERS THE PATTERN OF INTRAGRAFT APOPTOTIC ACTIVITY

摘要

BackgroundLiver allografts are accepted across major histocompatibility complex (MHC) barriers in mice and induce donor-specific tolerance without requirement for immunosuppressive therapy. There is evidence that passenger leukocytes may play a key role in tolerance induction. Flt-3 ligand (FL) is a recently cloned hematopoietic cytokine that strikingly augments functional dendritic cells (DCs) within lymphoid and nonlymphoid tissue.