Immune status and uptake of antiretroviral interventions to prevent mother-to-child transmission of HIV-1 in Africa

摘要

The aim of this study was to describe the distribution of CD4+ T cell count (CD4) of HIV-1 infected pregnant women diagnosed during prenatal counseling and testing (VCT), in Abidjan, Côte d’Ivoire, and to assess whether HIV-related immunodeficiency influenced or not the acceptance of an antiretroviral package to prevent mother-to-child transmission. Between April and June 2002, CD4 count was systematically performed in all women diagnosed as HIV-infected (n=221) in five antenatal clinics carrying out VCT. Their median CD4 was 408 cells/mm³ and 14% were < 200 CD4. The overall uptake of the intervention (31.9%) was independent of the immune status.