Induction and Reversal of Cardiac Phenotype of Human Hypertrophic Cardiomyopathy Mutation Cardiac Troponin T-Q92 in Switch on-Switch Off Bigenic Mice

摘要

ObjectivesTo establish reversibility of cardiac phenotypes in hypertrophic cardiomyopathy (HCM) by generating bigenic mice in which expression of the mutant transgene could be turned on and off as needed.