Post-mortem Locus Coeruleus Neuron Count in Three American Veterans with Probable or Possible War-Related PTSD

摘要

ObjectiveBecause enhanced CNS noradrenergic postsynaptic responsiveness has been previously shown to contribute to PTSD pathophysiology, we investigated whether war-related posttraumatic stress disorder (WR-PTSD) is associated with a post-mortem change in neuronal counts in the locus coeruleus (LC).