Proteomic investigation of human burn wounds by 2D-difference gel electrophoresis and mass spectrometry

摘要

BackgroundIn humans, thermal cutaneous injury represents a serious traumatic event that induces a host of dynamic alterations. Unfortunately the molecular mechanisms that underlie these serious perturbations remain poorly understood. We applied a global analysis method to identify dynamically changing proteins within the burn environment, which could eventually become biomarkers or targets for treatment.