Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder

摘要

ObjectiveGABAA receptors play an important regulatory role in the developmental events leading to the formation of complex neuronal networks and to the behaviors they govern. The primary aim of this study was to assess whether gabrb3 gene deficient (gabrb3^-/-) mice exhibit abnormal social behavior, a core deficit associated with autism spectrum disorder.