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Spectral filtering for improved pulsed photothermal temperature profiling in agar tissue phantoms

机译:光谱过滤可改善琼脂组织模型中的脉冲光热温度分布

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摘要

We present a systematic experimental comparison of pulsed photothermal temperature profiling utilizing the customary spectral band of the InSb radiation detector (λ=3.0 to 5.6 μm) and a narrowed acquisition band (4.5 to 5.6 μm). We use custom tissue phantoms composed of agar gel layers separated by thin absorbing layers. The laser-induced temperature profiles are reconstructed within the customary monochromatic approximation, using a custom minimization algorithm. In a detailed numerical simulation of the experimental procedure, we consider several acquisition spectral bands with the lower wavelength limit varied between 3.0 and 5.0 μm (imitating application of different long-pass filters). The simulated PPTR signals contain noise with amplitude and spectral characteristics consistent with our experimental system. Both experimental and numerical results indicate that spectral filtering reduces reconstruction error and broadening of temperature peaks, especially for shallower and more complex absorbing structures. For the simulated PPTR system and watery tissues, numerical results indicate an optimal lower wavelength limit of 3.8 to 4.2 μm.
机译:我们介绍了利用InSb辐射探测器的常规光谱带(λ= 3.0至5.6μm)和较窄的采集带(4.5至5.6μm)对脉冲光热温度分布进行系统的实验比较。我们使用由薄的吸收层隔开的琼脂凝胶层组成的定制组织体模。使用常规的最小化算法,在常规的单色近似值内重建激光诱导的温度曲线。在实验过程的详细数值模拟中,我们考虑了几个波长下限在3.0到5.0μm之间变化的采集光谱带(模拟了不同的长通滤波器的应用)。模拟的PPTR信号包含振幅和频谱特性与我们的实验系统一致的噪声。实验和数值结果均表明,光谱过滤可减少重建误差并扩大温度峰的范围,尤其是对于较浅和较复杂的吸收结构而言。对于模拟的PPTR系统和水基组织,数值结果表明最佳的波长下限为3.8至4.2μm。

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