Family History of Alcoholism Does Not Influence Adrenocortical Hyporesponsiveness in Abstinent Alcohol-Dependent Men

摘要

BackgroundEarly abstinence in alcohol-dependent subjects is marked by adrenocortical hyporesponsivity. However, it is uncertain whether the blunted response is primarily attributable to a genetic vulnerability or to the chronic abuse of alcohol. In the present study, the authors investigated the influence of a family history (FH) of alcoholism upon suppressed glucocorticoid reactivity.