Gene-environment interactions between CD14 C-260T and endotoxin exposure on Foxp3+ and Foxp3− CD4+ lymphocyte numbers and total serum IgE levels in early childhood

摘要

BackgroundInnate immune system stimuli, such as endotoxin, seem to affect allergy risk. Previously, we described gene-environment interactions between the endotoxin receptor polymorphism C-260T of the CD14 gene and endotoxin exposure on total serum IgE level; however, the mechanism of this interaction is not known.