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On Linear Infeasibility Arising in Intensity-Modulated Radiation Therapy Inverse Planning

机译:强度调制放射治疗逆向计划中的线性不可行性

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摘要

Intensity–modulated radiation therapy (IMRT) gives rise to systems of linear inequalities, representing the effects of radiation on the irradiated body. These systems are often infeasible, in which case one settles for an approximate solution, such as an {α, β}–relaxation, meaning that no more than α percent of the inequalities are violated by no more than β percent. For real-world IMRT problems, there is a feasible {α, β}–relaxation for sufficiently large α, β > 0, however large values of these parameters may be unacceptable medically.The {α, β}–relaxation problem is combinatorial, and for given values of the parameters can be solved exactly by Mixed Integer Programming (MIP), but this may be impractical because of problem size, and the need for repeated solutions as the treatment progresses.As a practical alternative to the MIP approach we present a heuristic non–combinatorial method for finding an approximate relaxation. The method solves a Linear Program (LP) for each pair of values of the parameters {α, β} and progresses through successively increasing values until an acceptable solution is found, or is determined non–existent. The method is fast and reliable, since it consists of solving a sequence of LP’s.
机译:调强放射疗法(IMRT)引起线性不等式系统,代表了辐射对被辐射物体的影响。这些系统通常是不可行的,在这种情况下,人们会寻求一种近似解,例如{α,β}-松弛,这意味着不超过α%的不等式违反了不超过β%。对于现实世界中的IMRT问题,对于足够大的α,β> 0,有一个可行的{α,β}-松弛,但是在医学上可能不接受这些参数的较大值。{α,β}-松弛问题是组合的,对于给定的参数值,可以通过混合整数编程(MIP)精确解决,但这可能不切实际,因为问题规模大,并且随着处理的进行需要重复求解。作为MIP方法的一种实际替代方案,我们提出寻找近似松弛的启发式非组合方法。该方法为参数{α,β}的每对值求解线性规划(LP),并逐步增加值直到找到可接受的解决方案或确定该解决方案不存在为止。该方法快速可靠,因为它包括求解一系列LP。

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