Developing Probability Distributions for Transfer Efficiencies for Dermal Exposure

摘要

Many dermal exposure models use stochastic techniques to sample parameter distributions derived from experimental data to more accurately represent variability and uncertainty. Transfer efficiencies represent the fraction of a surface contaminant transferred from a surface to the skin during a contact event. While an important parameter for assessing dermal exposure, examination of the literature confirms that no single study is large enough to provide the basis for a transfer efficiency distribution for use in stochastic dermal exposure models. It is therefore necessary to combine data sets from multiple studies to achieve the largest data set possible for distribution analysis. A literature review was conducted to identify publications reporting transfer efficiencies. Data sets were compared using the Kruskal-Wallis test to determine if they arise from the same distribution. Combined data were evaluated for several theoretical distributions using the Kolmogorov-Smirnov and Chi-square goodness-of-fit tests. Our literature review identified 35 studies comprising 25 different sampling methods, 25 chemicals, and 10 surface types. Distributions were developed for three different chemicals (chlorpyrifos, pyrethrin I, and piperonyl butoxide) on three different surface types (carpet, vinyl, and foil). Only the lognormal distribution was consistently accepted for each chemical and surface combination. Fitted distributions were significantly different (Kruskal Wallis test p<0.001) across chemicals and surface types. In future studies increased effort should be placed on developing large studies that more accurately represent transfer to human skin from surfaces and developing a normative transfer efficiency measure so that data from different methodologies can be compared.