Autosome-Wide Linkage Analysis of Hip Structural Phenotypes in the Old Order Amish

摘要

IntroductionFracture risk is associated with bone mineral density (BMD) and with other indices of bone strength, including hip geometry. While the heritability and associated fracture risk of BMD are well described, less is known about genetic influences of bone geometry. We derived hip structural phenotypes using the Hip Structural Analysis Program (HSA) and performed autosome-wide linkage analysis of hip geometric structural phenotypes.