Calcium Sensitive Adenylyl Cyclases in Depression and Anxiety: Behavioral and Biochemical Consequences of Isoform Targeting

摘要

BackgroundAdenylyl cyclases (ACs) represent a diverse family of enzymes responsible for the generation of cAMP, a key intracellular second messenger. Ca²⁺/calmodulin-stimulated AC1 and AC8 isoforms, as well as the calcium-inhibited AC5 isoform, are abundantly expressed within limbic regions of the central nervous system. This study examines the contribution of these AC isoforms to emotional behavior.