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Sex Differences in the Neurotoxic Effects of Adenosine A1 Receptor Antagonism During Ethanol Withdrawal: Reversal With an A1 Receptor Agonist or an NMDA Receptor Antagonist

机译：乙醇戒断期间腺苷A1受体拮抗作用的神经毒性中的性别差异：与A1受体激动剂或NMDA受体拮抗剂的逆转

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BackgroundNeuronal adaptations that occur during chronic ethanol (EtOH) exposure have been observed to sensitize the brain to excitotoxic insult during withdrawal. The adenosine receptor system warrants further examination in this regard, as recent evidence has implicated adenosine receptor involvement in the behavioral effects of both EtOH exposure and withdrawal.

机译：背景技术已观察到在慢性乙醇（EtOH）暴露期间发生的神经适应会在戒断期间使大脑对兴奋性毒性损伤敏感。腺苷受体系统在这方面值得进一步检查，因为最近的证据表明腺苷受体参与了EtOH暴露和戒断的行为影响。

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期刊名称 other
作者
Tracy R. Butler; Katherine J. Smith; Rachel L. Self; Brittany B. Braden; Mark A. Prendergast;
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作者单位

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年(卷),期 -1(32),7
年度 -1
页码 1260–1270
总页数 20
原文格式 PDF
正文语种
中图分类
关键词
Alcoholism Glutamate Brain Injury Gender;

机译：酒精中毒;谷氨酸盐;脑损伤;性别;

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专利

1. Sex differences in the neurotoxic effects of adenosine A1 receptor antagonism during ethanol withdrawal: reversal with an A1 receptor agonist or an NMDA receptor antagonist. [J] . Butler TR, Smith KJ, Self RL, Alcoholism: Clinical and experimental research . 2008,第7期

机译：乙醇戒断期间腺苷A1受体拮抗作用的神经毒性中的性别差异：用A1受体激动剂或NMDA受体拮抗剂逆转。
2. Species differences in structure‐activity relationships of adenosine agonists and xanthine antagonists at brain A1 adenosine receptors [J] . Ayala Cristina, Daly John W., Jacobson Kenneth A., FEBS Letters . 1986,第1期

机译：大脑A1腺苷受体上腺苷激动剂和黄嘌呤拮抗剂的构效关系的物种差异
3. The surmountable effect of FSCPX, an irreversible A1 adenosine receptor antagonist, on the negative inotropic action of A1 adenosine receptor full agonists in isolated guinea pig left atria [J] . Rudolf Gesztelyi, Zsuzsanna Kiss, Zita Wachal, Archives of Pharmacal Research . 2013,第3期

机译：不可逆的A1腺苷受体拮抗剂FSCPX对豚鼠左心房中A1腺苷受体完全激动剂的负性肌力作用的巨大作用
4. EFFECTS OF NMDA AND NON-NMDA RECEPTORS ANTAGONISTS ON THE BEHAVIOR OF CULTURED CORTICAL NETWORKS [C] . Laura Bonzano, Marco Bove, Sergio Martinoia Brain Inspired Cognitive Systems . 2004

机译：NMDA和非NMDA受体对拮抗剂对培养皮质网络行为的影响
5. Long-term effects of neurotoxic NMDA receptor antagonism and muscarinic activation on auditory gating and nicotinic receptor regulation in rats: Implications for models of schizophrenia. [D] . Rasmussen, Bruce A. 2006

机译：神经毒性NMDA受体拮抗作用和毒蕈碱活化对大鼠听觉门控和烟碱样受体调节的长期影响：对精神分裂症模型的影响。
6. Species differences in structure-activity relationships of adenosine agonists and xanthine antagonists at brain A1 adenosine receptors [O] . Dieter Ukena, Kenneth A. Jacobson, William L. Padgett, -1

机译：大脑A1腺苷受体在腺苷激动剂和黄嘌呤拮抗剂的构效关系上的物种差异
7. Species differences in structure-activity relationships of adenosine agonists and xanthine antagonists at brain A1 adenosine receptors [O] . Ukena Dieter, Jacobson Kenneth A., Padgett William L., 1986

机译：大脑A1腺苷受体上腺苷激动剂和黄嘌呤拮抗剂的构效关系的物种差异

Sex Differences in the Neurotoxic Effects of Adenosine A1 Receptor Antagonism During Ethanol Withdrawal: Reversal With an A1 Receptor Agonist or an NMDA Receptor Antagonist

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