Autoradiographic and Small-Animal PET Comparisons Between 18F-FMISO 18F-FDG 18F-FLT and the Hypoxic Selective 64Cu-ATSM in a Rodent Model of Cancer

摘要

IntroductionCu-ATSM, a hypoxia imaging agent, has been shown to be predictive of response to traditional cancer therapies in patients with a wide range of tumors. It is known that the environment of the tumor results in a myriad of physiological consequences, including hypoxia, alterations in metabolism and proliferation. In an effort to better characterize the relationships between Cu-ATSM and other prominent radiopharmaceuticals, this current study was undertaken to compare the regional distribution of ⁶⁴Cu-ATSM with ¹⁸F-FMISO, ¹⁸F-FDG and ¹⁸F-FLT in 9L tumors.