Generalized and Neurotransmitter-Selective Noradrenergic Denervation in Parkinson Disease with Orthostatic Hypotension

摘要

BackgroundPatients with Parkinson disease (PD) often have manifestations of autonomic failure. About 40% have neurogenic orthostatic hypotension (NOH), and among PD+NOH patients virtually all have evidence of cardiac sympathetic denervation; however, whether PD+NOH entails extra-cardiac noradrenergic denervation has been less clear.