Evaluation of a Scoring System for Assessing Prognosis in Pediatric Acute Liver Failure

摘要

Background & AimsPediatric acute liver failure (PALF) results in death or need for liver transplantation (LT) in up to 50% of patients. A scoring system for predicting death or LT [Liver Injury Units (LIU) score] in PALF was previously derived by our group, and used peak values during hospital admission of total bilirubin, prothrombin time/international normalized ratio, and ammonia as significant predictors of outcome. The aims of this study were to test the predictive value of the LIU score in a subsequent validation set of patients and to derive a hospital admission score (aLIU) predictive of outcome.