Polymorphism in the CETP Gene Region HDL Cholesterol and Risk of Future Myocardial Infarction: Genomewide Analysis among 18245 Initially Healthy Women from the Women’s Genome Health Study

摘要

BackgroundRecent trial data have challenged the hypothesis that cholesteryl ester transfer protein (CETP) and high-density lipoprotein cholesterol (HDLC) have causal roles in atherothrombosis. One method to evaluate this issue is to examine whether polymorphisms in the CETP gene that impact on HDLC levels also impact on the future development of myocardial infarction.