Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view

摘要

The directed movement of chromosomes during mitosis and meiosis relies on microtubule-mediated connection between the spindle poles and kinetochores assembled on chromosomes. The molecular basis for the dynamic interaction between microtubules and kinetochores is just beginning to be unveiled. Here, focusing on the mitotic centromere kinase Aurora B, we review our current understanding of the signaling pathways that correct erroneous microtubule attachment at kinetochores. We evaluate several potential models that may explain how maloriented attachments can be recognized and processed by the Aurora B pathway.