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Functional involvement of protein kinase C-βII and its substrate myristoylated alanine-rich C-kinase substrate (MARCKS) in insulin-stimulated glucose transport in L6 rat skeletal muscle cells

机译：蛋白激酶C-βII及其底物（富含肉豆蔻酰的富含丙氨酸的C激酶底物（MARCKS））在L6大鼠骨骼肌细胞中胰岛素刺激的葡萄糖转运中的功能参与

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Aims/hypothesisInsulin stimulates phosphorylation cascades, including phosphatidylinositol-3-kinase (PI3K), phosphatidylinositol-dependent kinase (PDK1), Akt, and protein kinase C (PKC). Myristoylated alanine-rich C-kinase substrate (MARCKS), a PKCβII substrate, could link the effects of insulin to insulin-stimulated glucose transport (ISGT) via phosphorylation of its effector domain since MARCKS has a role in cytoskeletal rearrangements.

机译：目的/假设胰岛素刺激磷酸化级联反应，包括磷脂酰肌醇-3-激酶（PI3K），磷脂酰肌醇依赖性激酶（PDK1），Akt和蛋白激酶C（PKC）。由于MARCKS在细胞骨架重排中起作用，因此富含肉豆蔻酰化的富含丙氨酸的C激酶底物（MARCKS），即PKCβII底物，可以通过其效应子结构域的磷酸化将胰岛素的作用与胰岛素刺激的葡萄糖转运（ISGT）联系起来。

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期刊名称 other
作者
D. S. Chappell; N. A. Patel; K. Jiang; P. Li; J. E. Watson; D. M. Byers; D. R. Cooper;
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年(卷),期 -1(52),5
年度 -1
页码 901–911
总页数 20
原文格式 PDF
正文语种
中图分类
关键词
F-actin Glucose transporter 4 Insulin-stimulated glucose uptake L6 myocytes MARCKS Phospholipase D1 PKCβ;

机译：F-肌动蛋白;葡萄糖转运蛋白4;胰岛素刺激的葡萄糖摄取;L6心肌细胞;MARCKS;磷脂酶D1;PKCβ;

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专利

1. Functional involvement of protein kinase C-βII and its substrate, myristoylated alanine-rich C-kinase substrate (MARCKS), in insulin-stimulated glucose transport in L6 rat skeletal muscle cells [J] . D. S. Chappell, N. A. Patel, K. Jiang, Diabetologia . 2009,第5期

机译：蛋白激酶C-βII及其底物（富含肉豆蔻酰的富含丙氨酸的C激酶底物（MARCKS））在L6大鼠骨骼肌细胞中胰岛素刺激的葡萄糖转运中的功能参与
2. Effects of insulin and phorbol esters on MARCKS (myristoylated alanine-rich C-kinase substrate) phosphorylation (and other parameters of protein kinase C activation) in rat adipocytes, rat soleus muscle and BC3H-1 myocytes [J] . D R Cooper, H Hernandez, H Mischak, The biochemical journal . 1993,第1期

机译：胰岛素和佛波酯对大鼠脂肪细胞，比目鱼肌和BC3H-1心肌细胞MARCKS（富含豆蔻酰化的富含丙氨酸的C激酶底物）磷酸化（以及其他蛋白激酶C活化的参数）的影响
3. Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein [J] . GreenT.D., ParkJ., YinQ., Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2012,第3期

机译：小鼠巨噬细胞在体外的定向迁移涉及富含肉豆蔻酰化的富含丙氨酸的C激酶底物（MARCKS）蛋白
4. Cortisol and IGF-1 synergistically up-regulate taurine transport by the rat skeletal muscle cell line, L6 [C] . Sung-Hee Park, Haemi Lee, Taesun Park International Conference on Food Factors . 2004

机译：皮质醇和IGF-1通过大鼠骨骼肌细胞系L6协同上调牛磺酸传输
5. Molecular Roles of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) in Neurite Dynamics [D] . Brudvig, Jonathan Jazz. 2018

机译：神经沸石动力学中富氮氧化族富含丙氨酸富含C激酶底物（Marcks）的分子作用
6. Effects of insulin and phorbol esters on MARCKS (myristoylated alanine-rich C-kinase substrate) phosphorylation (and other parameters of protein kinase C activation) in rat adipocytes rat soleus muscle and BC3H-1 myocytes. [O] . T P Arnold, M L Standaert, H Hernandez, 1993

机译：胰岛素和佛波醇酯对大鼠脂肪细胞大鼠比目鱼肌和BC3H-1心肌细胞中MARCKS（富含豆蔻酰化的富含丙氨酸的C激酶底物）磷酸化（以及蛋白激酶C活化的其他参数）的影响。
7. Functional involvement of protein kinase C-βII and its substrate, myristoylated alanine-rich C-kinase substrate (MARCKS), in insulin-stimulated glucose transport in L6 rat skeletal muscle cells [O] . D. S. Chappell, N. A. Patel, K. Jiang, 2009

机译：蛋白激酶C-βII及其基质，富硒氧化丙氨酸富含C-激酶底物（MARCK），在L6大鼠骨骼肌细胞中的胰岛素刺激的葡萄糖转运中的功能介入

Functional involvement of protein kinase C-βII and its substrate myristoylated alanine-rich C-kinase substrate (MARCKS) in insulin-stimulated glucose transport in L6 rat skeletal muscle cells

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