Chemoinformatic Methods for Predicting Interference in Drug of Abuse/Toxicology Immnoassays

摘要

BackgroundImmunoassays used for routine drug of abuse (DOA) and toxicology screening may be limited by cross-reacting compounds able to bind to the antibodies in a manner similar to the target molecule(s). To date, there has been little systematic investigation using computational tools to predict cross-reactive compounds.