Circadian timing of ethanol exposure exerts enduring effects on subsequent ad libitum consumption in C57 mice

摘要

BackgroundThere is a daily rhythm in the voluntary intake of ethanol in mice, with greatest consumption in the early night and lowest intake during the day. The role of daily timing of ethanol exposure on the development and control of long-term ethanol self-administration has been neglected. The present study examines these issues using C57BL/6J mice.