Candidate Loci for Insulin Sensitivity and Disposition Index from a Genome Wide Association Analysis of Hispanics in the IRAS Family Study

摘要

Aims/Hypothesis>—The majority of type 2 diabetes Genome Wide Association Studies (GWAS) to date have been performed in European-derived populations and have identified few variants that mediate their effect through insulin resistance. The aim of this study was to evaluate two quantitative, directly assessed measures of insulin resistance (SI and DI) in Hispanic Americans using an agnostic, high-density SNP scan and validate these findings in additional samples.