AN FMRI STUDY OF WORKING MEMORY IN PERSONS WITH BIPOLAR DISORDER OR AT GENETIC RISK FOR BIPOLAR DISORDER

摘要

BACKGROUNDFirst-degree relatives of persons with bipolar disorders (BD) carry elevated risk for the illness, and manifest deficits in attention and memory (possible “endophenotypes”). However, there is only one published fMRI study of candidate endophenotypes in BD. We used functional magnetic resonance imaging (fMRI) to examine brain function in BD and in first-degree relatives performing a 2-back working memory (WM) task, and correlated brain activity with mood measures taken at the scanning session.