Randomized Phase II Study of Gemcitabine Plus Radiotherapy vs. Gemcitabine 5-Fluorouracil and Cisplatin Followed by Radiotherapy and 5-Fluorouracil for Patients with Locally Advanced Potentially Resectable Pancreatic Adenocarcinoma

摘要

PurposeA randomized phase II trial (E1200) was designed to assess toxicities and surgical resection rates in two neoadjuvant gemcitabine-based chemoradiation regimens in patients with borderline resectable pancreatic cancer. The trial was terminated early due to poor accrual.