Artificial Pancreas Systems: Glucose Clamp Algorithms and Insulin Time-Action Profiles

摘要

MotivationMost current insulin pumps include an insulin-on-board (IOB) feature to help subjects avoid problems associated with “insulin stacking.” In addition, many control algorithms proposed for a closed-loop artificial pancreas make use of IOB to reduce the probability of hypoglycemic events that often occur due to the integral action of the controller. The IOB curves are generated from the pharmacodynamic (time-activity profiles) actions of subcutaneous insulin, which are obtained from glycemic clamp studies.