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Polynitroxylated Pegylated Hemoglobin: A Novel Neuroprotective Hemoglobin for Acute Volume-Limited Fluid Resuscitation after Combined Traumatic Brain Injury and Hemorrhagic Hypotension in Mice

机译：多尼氮化聚乙二醇化血红蛋白：组合创伤性脑损伤和小鼠出血性低血压后的急性体积计流体复苏的新型神经保护血红蛋白

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ObjectiveResuscitation of hemorrhagic hypotension after traumatic brain injury (TBI) is challenging. A hemoglobin (Hb)-based oxygen carrier (HBOC) may offer advantages. The novel therapeutic HBOC, polynitroxylated pegylated Hb (PNPH) may represent a neuroprotective HBOC for TBI resuscitation.

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期刊名称 other
作者
David K. Shellington; Lina Du; Xianren Wu; Jennifer Exo; Vincent Vagni; Li Ma; Keri Janesko-Feldman; Robert S.B. Clark; Hülya Bayır; C. Edward Dixon; Larry W. Jenkins; Carleton J.C. Hsia; Patrick M. Kochanek;
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年(卷),期 -1(39),3
年度 -1
页码 494–505
总页数 29
原文格式 PDF
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head injury hemoglobin based oxygen carrier nitroxide oxidative stress nitric oxide polyethylene glycol hemorrhagic shock blast injury polytrauma blood substitute polynitroxylation superoxide;

机译：颅脑损伤;基于血红蛋白的氧气载体;一氧化氮;氧化应激;一氧化氮;聚乙二醇;失血性休克;冲击波损伤;多创伤;血液替代品;多硝基氧化;超氧化物;

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1. Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice. [J] . Shellington DK, Du L, Wu X, Critical care medicine . 2011,第3期

机译：多硝基氧化聚乙二醇化血红蛋白：一种新型的神经保护性血红蛋白，可用于小鼠颅脑外伤和出血性低血压合并后的急性容量受限的液体复苏。
2. Polynitroxylated-pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice [J] . BrockmanE.C., BayirH., BlasioleB., Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 2013,第9期

机译：多硝基羟化聚乙二醇化血红蛋白可减轻小鼠颅脑外伤加失血性休克的体液需求和脑水肿
3. Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock [J] . Soichiro Seno, Jun Wang, Suyi Cao, BMC Neuroscience . 2020,第1期

机译：用大分子超氧化物歧化酶/过氧化氢酶模拟多尼氮杂化的聚乙二醇化血红蛋白为豚鼠进行神经保护剂，在创伤性脑损伤结合出血冲击后
4. Neuroprotective and neurorestorative effects of thymosin β4 treatment following experimental traumatic brain injury [C] . Ye Xiong, Asim Mahmood, Yuling Meng, International Symposium on Thymosins in Health and Disease . 2012

机译：实验创伤脑损伤后胸腺素β4治疗的神经保护和神经口感效应
5. Neuroprotective efficacy of minocycline after intracerebral hemorrhage and possible Kv1.3, Kv1.5, HERG and alpha7 nAChR channels as targets for regulating secondary brain injury in hemorrhagic and ischemic stroke. [D] . Yerneni, Tejaswi. 2005

机译：脑出血后米诺环素的神经保护功效以及可能的Kv1.3，Kv1.5，HERG和alpha7 nAChR通道作为调节出血性和缺血性中风继发性脑损伤的靶标。
6. Polynitroxylated-pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice [O] . Erik C Brockman, Hülya Bayır, Brian Blasiole, 2013

机译：多硝基羟化聚乙二醇化血红蛋白可减轻小鼠颅脑外伤加失血性休克的体液需求和脑水肿
7. Polynitroxylated pegylated hemoglobin: A novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice* [O] . David K. Shellington, Lina Du, Xianren Wu, 2011

机译：多尼氧化的聚乙二醇化血红蛋白：组合创伤性脑损伤和小鼠出血性低血压后的急性体积计流体复苏的新型神经保护血红蛋白*
8. Diaspirin Cross-Linked Hemoglobin Infusion Did Not Influence Base Deficit and Lactic Acid Levels in Two Clinical Trials of Traumatic Hemorrhagic Shock Patient Resuscitation [R] . Sloan, E. P., Koenigsberg, M. D., Philbin, N. B., 2010

机译：Diaspirin交联血红蛋白输注未影响创伤性失血性休克患者复苏的两项临床试验中的基础缺陷和乳酸水平

Polynitroxylated Pegylated Hemoglobin: A Novel Neuroprotective Hemoglobin for Acute Volume-Limited Fluid Resuscitation after Combined Traumatic Brain Injury and Hemorrhagic Hypotension in Mice

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