Usefulness of Single Nucleotide Polymorphism in Chromosome 4q25 to Predict In-Hospital and Long Term Development of Atrial Fibrillation and Survival in Patients Undergoing Coronary Artery Bypass Grafting

摘要

We aimed to determine whether polymorphisms in chromosome 4q25 are associated with postoperative atrial fibrillation (AF), long term AF, postoperative or long term stroke, and long term survival after coronary artery bypass grafting (CABG). We performed genotyping for rs2200733 and rs10033464 in Caucasian participants (n=1,166) of TexGen genetic registry. Development of postoperative or long term AF, postoperative or long term stroke, and long term mortality were ascertained. Both rs2200733 and rs10033464 were associated with postoperative AF (odds ratio [OR]=1.41, 95% confidence interval [CI]; 1.04–1.91, and OR=1.47, 95% CI; 1.05–2.06, respectively). Carriers of the risk allele (T) had an increased risk of postoperative AF with preoperative beta blocker (BB) (for rs2200733: OR=1.47, 95% CI; 1.004–2.16 for those on BB, and OR=1.13, 95% CI; 0.73–1.73 for those not on BB; for rs10033464: OR=1.89, 95% CI; 1.22–2.93 for those on pre-operative BB, and OR=1.04, 95% CI; 0.65–1.65 for those not on BB). Both rs2200733 and rs10033464 were also associated with long term AF (hazards ratio [HR]=1.32, 95% CI; 1.05–1.67, and HR=1.28, 95% CI; 1.00–1.66, respectively). Carriers of rs2200733 had increased long term mortality (HR=1.57, 95% CI; 1.10–2.24). These variants were not associated with postoperative or long term stroke. In conclusion, variants in 4q25 are associated with an increased risk of postoperative or long term AF, and possibly mortality in Caucasians undergoing CABG, and could potentially affect the choice of therapy used to decrease postoperative AF.