Elevated hepatic fatty acid oxidation high plasma fibroblast growth factor 21 and fasting bile acids in nonalcoholic steatohepatitis

摘要

BackgroundData from studies in patients with nonalcoholic steatohepatitis (NASH) suggest an increased hepatic fatty acid oxidation. We have previously shown higher fasting plasma bile acid concentrations in patients with NASH. In-vivo and in-vitro studies suggest that bile acids by binding to peroxisome proliferator-activated receptor α activate fibroblast growth factor 21 (FGF21) and increase hepatic fatty acid oxidation.