In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug delivery system: enhanced efficacy by folate modification

摘要

Mesoporous Silica Nanoparticles (MSNs) have proven to be promising vehicles for drug delivery. However, despite the potential, there are few studies that extended the success of in vitro studies to animal settings. In this work, we report the efficacy of MSNs using two different human pancreatic cancer xenografts on different mouse species. Significant tumor-suppression effects were achieved with camptothecin-loaded MSNs. Dramatic improvement of the potency of tumor suppression was obtained by surface modifying MSNs with folic acid. Dose dependent tumor suppression was observed establishing 0.5 mg of CPT-loaded MSNs per mouse as a minimum dose sufficient for achieving complete tumor growth inhibition. Renal excretion of MSNs was also confirmed with TEM imaging. These findings highlight attractive features (biocompatibility, renal clearance and tumor-suppressing ability) of MSNs as a drug delivery system.