Increased IL-1 beta gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis

摘要

ObjectiveWe examined gene expression profiles in peripheral blood leukocytes (PBL) of patients with osteoarthritis (OA) in comparison with non-OA controls to evaluate whether gene expression profiles could serve as biomarkers of symptomatic knee OA. We also determined whether candidate genomic biomarkers (PBL expression of inflammatory genes) predict increased risk of disease progression in subjects with symptomatic radiographic knee OA