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3′-Deoxy-3′-18FFluorothymidine Positron Emission Tomography for Response Assessment in Soft Tissue Sarcoma: A Pilot Study to Correlate Imaging Findings With Tissue Thymidine Kinase 1 and Ki-67 Activity and Histopathologic Response

机译：3-脱氧-3 - 18F软组织Sarcoma中响应评估的含氟脱氨酸正电子发射断层扫描：试验研究与组织胸苷激酶1和Ki-67活性和组织病理学反应相关性研究

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BACKGROUNDThis study sought to determine whether [¹⁸F]fluorothymidine (FLT) positron emission tomography (PET)/computed tomography (CT) imaging allows assessment of tumor viability and proliferation in patients with soft tissue sarcomas who are treated with neoadjuvant therapy.

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期刊名称 other
作者
Matthias R. Benz; Johannes Czernin; Martin S. Allen-Auerbach; Sarah M. Dry; Piriya Sutthiruangwong; Claudio Spick; Caius Radu; Wolfgang A. Weber; William D. Tap; Fritz C. Eilber;
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年(卷),期 -1(118),12
年度 -1
页码 3135–3144
总页数 17
原文格式 PDF
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关键词
FLT PET/CT sarcoma Ki-67 TK1;

机译：FLT;PET / CT;肉瘤;Ki-67;TK1;

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专利

1. 3′-deoxy-3′-[ 18F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma: A pilot study to correlate imaging findings with tissue thymidine kinase 1 and Ki-67 activity and histopathologic response [J] . BenzM.R., CzerninJ., Allen-AuerbachM.S., Cancer: A Journal of the American Cancer Society . 2012,第12期

机译：3'-脱氧-3'-[18F]氟胸腺嘧啶正电子发射断层显像在软组织肉瘤中的反应评估：一项将成像结果与组织胸苷激酶1和Ki-67活性及组织病理学反应相关的先导研究
2. An Assessment of Early Response to Targeted Therapy via Molecular Imaging: A Pilot Study of 3′-deoxy-3′[(18)F]-Fluorothymidine Positron Emission Tomography 18 F-FLT PET/CT in Prostate Adenocarcinoma [J] . Kalevi Kairemo, Gregory C. Ravizzini, Homer A. Macapinlac, Diagnostics . 2017,第2期

机译：通过分子成像评估对靶向治疗的早期反应：3'-脱氧-3'[（18）F]-氟胸苷正电子发射断层显像18 F-FLT PET / CT在前列腺腺癌中的初步研究
3. Magnetic resonance imaging and positron emission tomography-computed tomography evaluation of soft tissue sarcoma with surgical and histopathological correlation [J] . Nauroze Asghar Faizi, Sanjay Thulkar, Raju Sharma, Indian Journal of Nuclear Medicine . 2012,第4期

机译：磁共振成像和正电子发射断层扫描计算机断层扫描评估软组织肉瘤的手术和组织病理学关系
4. Computational analysis of optical coherence tomography images for the detection of soft tissue sarcomas [C] . Shang Wang, Narendran Sudheendran, Chih-Hao Liu, Conference on dynamics and fluctuations in biomedical photonics IX . 2013

机译：光学相干断层扫描图像的计算分析，用于检测软组织肉瘤
5. Investigation of [fluorine-18]fluoro-L-thymidine with positron emission tomography to assess radiotherapy response. [D] . Dick, David Wayne. 2004

机译：用正电子发射断层扫描技术研究[氟-18]氟-L-胸腺嘧啶核苷，以评估放射治疗的反应。
6. An Assessment of Early Response to Targeted Therapy via Molecular Imaging: A Pilot Study of 3′-deoxy-3′(18)F-Fluorothymidine Positron Emission Tomography 18F-FLT PET/CT in Prostate Adenocarcinoma [O] . Kalevi Kairemo, Gregory C. Ravizzini, Homer A. Macapinlac, 2017

机译：通过分子成像评估对靶向治疗的早期反应：3-脱氧-3（18）F-氟胸苷正电子发射断层显像18F-FLT PET / CT的初步研究
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

3′-Deoxy-3′-18FFluorothymidine Positron Emission Tomography for Response Assessment in Soft Tissue Sarcoma: A Pilot Study to Correlate Imaging Findings With Tissue Thymidine Kinase 1 and Ki-67 Activity and Histopathologic Response

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