GASTRIC BYPASS SURGERY RESTORES MEAL STIMULATION OF THE ANOREXIGENIC GUT HORMONES GLUCAGON-LIKE PEPTIDE-1 AND PEPTIDE YY INDEPENDENTLY OF CALORIC RESTRICTION

摘要

BackgroundThe effects of gastric bypass surgery on the secretion of the anorexogenic gut-derived hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), independent of caloric restriction and due to different dietary macronutrients, is not well-characterized. This study examines the effects of a mixed-nutrient or high-fat liquid meal on the postprandial stimulation of GLP-1 and PYY following gastric bypass or equivalent hypocaloric diet.