Late to the Party: Importance of Dietary Fat and Protein in the Intensive Management of Type 1 Diabetes. A Case Report

摘要

Insulin dosing in type 1 diabetes (T1D) has been focused primarily on carbohydrate intake, but recent evidence highlights the importance of dietary fat and protein in glycemic excursions. Several methods have been developed to incorporate dietary fat and protein into insulin dose calculations, including fat–protein units (FPUs) that estimate insulin requirements based on ingested fat and protein, as well as extended combination insulin boluses. However, insulin dosing based on meal fat and protein content is challenging to incorporate into clinical practice.We present the case of a 40-year-old man with T1D using continuous subcutaneous insulin infusions and continuous glucose monitoring. He followed a diet that restricted carbohydrate intake, with compensatory increases in dietary protein and fat. He had poor glycemic control with frequent postprandial hyperglycemia. He began incorporating FPUs into his insulin dosing calculations and used extended dual wave boluses to administer prandial insulin. Over the next 6 months he experienced a significant improvement in glycemic control.Fat and protein have both been shown to cause delayed postprandial hyperglycemia, leading to poor glycemic control with carbohydrate-focused insulin dosing in our patient on a high-fat, high-protein diet. It is difficult to incorporate dietary fat and protein into insulin dosing in the clinical setting. However, our patient experienced an improvement in glycemic control with the application of FPUs and dual wave boluses in prandial insulin dosing, showing that methods such as these can be used successfully in T1D management.